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Idiopathic hypersomnia is a debilitating neurologic sleep disorder characterized by chronic excessive daytime sleepiness, making it difficult to stay awake and alert during the day. People with idiopathic hypersomnia can sleep for adequate amounts of time each night but still feel excessively sleepy during the day.
Learn about XYWAV® (calcium, magnesium, potassium, and sodium oxybates) and the multiple symptoms of Idiopathic Hypersomnia. See full Prescribing Information & BOXED Warning about serious side effects, CNS depression, and misuse and abuse.
Apr 1, 2025 · Overview Lumryz, Xyrem and Xywav are mediated by GABAB receptor activity at noradrenergic, dopaminergic, and thalamocortical neurons. Wakix a histamine-3 (H3) receptor antagonist/inverse agonist. These medications are approved for cataplexy or excessive daytime sleepiness in narcolepsy. Xywav is also approved for the treatment of idiopathic hypersomnia.
Apr 11, 2024 · Xywav was originally FDA-approved in 2002 to treat excessive daytime sleepiness (EDS) and cataplexy (sudden muscle weakness triggered by strong emotions) in people at least 7 years old who have narcolepsy.
Could XYWAV be right for your adult patients with Idiopathic Hypersomnia (IH)? XYWAV is the only FDA-approved treatment for IH. 1,2 Consider XYWAV—a treatment taken each night to help manage multiple daily symptoms of IH, such as excessive daytime sleepiness (EDS), sleep inertia, cognitive impairment, and prolonged sleep time. 1
The safety and effectiveness of XYWAV for the treatment of cataplexy or excessive daytime sleepiness in pediatric patients 7 years of age and older with narcolepsy have been established.
XYWAV is the first and only FDA-approved medication to treat IH in adults. XYWAV has been studied across multiple symptoms of IH, such as excessive daytime sleepiness, sleep inertia, cognitive impairment, and long sleep time.
Jun 16, 2025 · Xywav is also approved to treat excessive daytime sleepiness and cataplexy (sudden muscle weakness) related to narcolepsy. Side effects of Xywav when used to treat these narcolepsy-related ...
May 5, 2025 · Xywav is used for the treatment of cataplexy and excessive daytime sleepiness (EDS) in patients with narcolepsy, and idiopathic hypersomnia (IH). Includes Xywav side effects, interactions and indications.
FDA-Approved Indications Xywav is indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.
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